UMass Boston Biology Club

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BioSpace is pleased to present the Pfizer BS/MS Level Science Career Fair on Thursday, November 29th at The Cambridge Center Marriott in Cambridge, MA from 11:00 a.m. to 5:30 p.m.

For this event, Pfizer Hiring Managers are SPECIFICALLY looking for BS/MS level candidates (dec/may grads are encouraged to attend) to fill numerous open positions in areas such as:

Biology Associate Scientist/Senior Associate Scientist – In Vivo/In Vitro
Biology Scientist/Senior Scientist – In Vivo/In Vitro
Synthetic Organic Chemist

Visit http://biospace.com/pfizeropenhousecambridge to Pre-Register Now!

Pfizer BS/MS Level Science Career Fair
Thursday, November 29th
Cambridge Center Marriott
Cambridge, MA
11:00 am to 5:30 pm

Different people. Different perspectives. One common commitment.

At Pfizer, we know we can make a difference in the quality of life for millions of individuals worldwide. We also understand that your talent is key to accomplishing this goal. Currently, we are the number one pharmaceutical company in every major market around the world. We are also consistently recognized as one of the nation's best employers and most admired companies. Much of our achievement comes from the importance we place on fulfilling our mission and values, as well as creating an environment that fosters the growth and development of our people.

Colleagues from around the world are drawn to Pfizer because of the challenging and often groundbreaking work we do, our emphasis on innovation, and our industry leadership. They stay at Pfizer because of our commitment to their growth and development, the respect we show them as individuals, our emphasis on creativity, diversity and inclusion, and our corporate values and leader behaviors.

The UMass Boston Biology Club is planning a fantastic trip to the Nantucket Field Station on Columbus Day Weekend!! This is a great research and educational opportunity. We will have guest speakers such as Dr. Hagar and others to give lectures about the research facility, the area surrounding, and diversity seen there as well as subject specialties. Come and join the fun!!!

Meeting to discuss upcoming events and other issues.

Aniline & Anhydride
the primary attack

-amide synthesis-
[vacuum filtration/recrystallization]

Spencer Lewis
Chemistry 254 Lab
3/8/2007

A B S T R A C T

Acetanilide is synthesized via the reaction that occurs when Aniline and Sodium Acetate interact. Before launching on this daunting expedition of creating Acetanilide, it would be wise to review a few concepts to confirm our understanding. Review will be followed by a reinforcement of the physical properties of chemicals involved in this reaction. Finally, we will observe lab procedure and translate results.
Perhaps the reader is already confused. :)
Aniline is a primary amine, a molecule containing a nitrogen atom only bonded to one carbon atom. Remember that nitrogen atoms possessing three bonds have a neutral charge as well as a lone pair of electrons for reacting with nucleophiles. A primary amine, Aniline for example, makes two other bonds with hydrogen to attain a neutral charge.
An anhydride is the result of dehydrating acids, for instance two molecules of ethanoic acid. Such dehydrations can occur by addition of P205 at a temperature of 80 degrees centigrade. The result is ethanoic anhydride or acetic anhydride.
The relevance of this experiment was to understand the synthesis of an amide. Amides are found in multiple compounds, for instance “penicillin V (a secondary amide) and polypeptides (amino acid sequences linked by amide bonds).” (Lab Manual p. 139) In this particular experiment, an acyl substitution reaction between the lone pair of electrons on the primary amine (Aniline) and the acetyl group of the Acetic Anhydride created a secondary amide, namely acetanilide. (This experiment was performed by using familiar techniques such as vacuum filtration and recrystallization.)

P H Y S I C A L P R O P E R T I E S

Chemical
Name
Molecular Formula
Molecular
Weight
(g/mol)
Denisty
(g/mL)
Melting Point
(C)
Boiling Point
(C )

The Grignard

Spencer Lewis
Chemistry 254 Lab
3/14-28/2007

A B S T R A C T

A Grignard Reaction is an Organometallic Chemical Reaction. An organometallic molecule consists of some metal along with one or more alkyl radicals. (Dictionary of Science, Barnhart. p. 456) (In this experiment, an organometallic molecule reacted with a ketone, namely Benzophenone.) When a Grignard Reagent reacts with a ketone, a tertiary alcohol is produced. It is, therefore, hypothesized that the resulting product of the reaction between Phenylmagnesium Bromide and Benzophenone will result if the formation of Triphenyl methanol.
What is a Grignard? one may ask. A Grignard Reagent is formed when an alky halide reacts with magnesium and diethyl ether. A Grignard Reagent is one of several familiar nucleophiles. When synthesizing various compounds, the Grignard Reagent is a useful means of adding carbons to carbonyl compounds. It is comprised of two main steps: 1.) Addition of Grignard, 2.) Hydrolysis.
The purpose of this laboratory was to become familiar with the Grignard Reagent and its reaction mechanism, as it was an emphasized topic in lecture. Grignards react with Carboxylic Acid derivatives as well as a plethora of other electrophiles. The interaction between a Grignard with a Class II Carbonyl Compound results in a tetrahedral product, resulting in a tertiary alcohol.
The Grignard Reagent is a useful nucleophile. As such, it is a useful reducing agent. Unfortunately, the metallic compound is very reactive with water (or any other protic solvent, really) so extra precautions were taken to assure a moisture-free environment for better reaction conditions. The glassware was oven dried, an air condenser was attached, and diethyl ether was used to create a protective barrier from atmospheric humidity. If the Grignard reacts with water, the tertiary alcohol will not be formed.

P H S I C A L P R O P E R T I E S

ChemicalName

For all interested parties, let me share what's been goin on lately.
The Bio officers, recently assembled for the first time of the semester, have done a very good job of organizing Nantucket as well as other aspects of the Biology Club this semester. We haven't been terribly active, true, but everyone has been pretty busy this semester with classes and work and whatnot.
However, it seems that the student senate has managed to go through approximately $500,000 in merely a semester. Because of this, there are no longer funding requests available, which may mean the inability to go to Nantucket this Spring and may mean that the Bio Club can't get shirts, a new annual tradition.
I'm so disappointed with the school at times like this. We are the students. We pay the money, and we should be able to use the money as we see fit. This is logical though, no?
Getting frustrated with a failing system. The students, needless to say, are not pleased

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On a lighter note, this blogger system can be used for online tutoring. If students have questions or concerns, they can post the problem and anyone who knows the answer can respond (citing sources, of course).

So this site is one good things, I suppose. Thanks Jay/Jessie/God/Jesus/et al

Trip to Nantucket Island